Thursday, November 3, 2011

Clinical Alert from The National Heart, Lung, and Blood Institute (NHLBI)

Commonly Used Three-drug Regimen for Idiopathic Pulmonary Fibrosis Found Harmful.

The National Heart, Lung and Blood Institute (NHLBI), part of the National Institutes of Health, has stopped one arm of a three arm multi-center, clinical trial studying treatments for the lung-scarring disease idiopathic pulmonary fibrosis (IPF) for safety concerns.

The trial found that people with IPF receiving a currently used triple-drug therapy consisting of prednisone, azathioprine, and N-acetylcysteine (NAC) had worse outcomes than those who received placebos or inactive substances.

Detailed information on this clinical alert can be found at: http://www.nlm.nih.gov/databases/alerts/2011_nhlbi_ifp.html

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